- Apr 4 39th NCAA Women's Basketball Championship: Stanford Cardinal defeat Arizona Wildcats, 54–53 to win their third NCAA title
- Apr 5 82nd NCAA Men's Basketball Championship: Baylor Bears become second consecutive first-time NCAA champions with 86–70 over previously undefeated Gonzaga Bulldogs
- Apr 9 San Diego Padres pitcher Joe Musgrove no-hits the Texas Rangers, 3-0 at Globe Life Field, Arlington, TX
- Apr 11 85th US Masters Tournament, Augusta National GC: Hideki Matsuyama become first Japanese male to win a golf major; hangs on to beat American Will Zalatoris by 1 stroke
- Apr 14 Chicago White Sox pitcher Carlos Rodón no-hits the Cleveland Indians, 8-0 at Guaranteed Rate Field, Chicago
- Apr 17 San Jose Sharks forward Patrick Marleau ties Gordie Howe's NHL record for most regular season games played at 1,767
- Apr 18 12-team European Super League is announced to widespread condemnation amongst governments, non-involved clubs, press and fans; amidst the furore all 6 EPL clubs withdraw within 3 days
- Apr 19 In Las Vegas, Nevada: San Jose Sharks forward Patrick Marleau breaks Gordie Howe's NHL record for most games played, now at 1,768 and counting
- Apr 20 All six EPL clubs withdraw from the controversial European Super League just 3 days after it was announced - Chelsea, Manchester City, Liverpool, Arsenal, Manchester United and Tottenham