- May 4 72nd Kentucky Derby: Warren Mehrtens aboard Assault wins in 2:06.6
- May 8 MLB Boston Red Sox shortstop Johnny Pesky scores 6 runs in 14-10 win over visiting Chicago White Sox
- May 10 Red Sox win 15th straight beat Yanks 5-4, DiMaggio hits Grand Slam
- May 11 1st night game at Boston Braves Field (Giants 5, Braves 1)
- May 11 71st Preakness: Warren Mehrtens aboard Assault wins in 2:01.4
- May 20 Cubs Claude Passeau makes his 1st error since September 21, 1941, ending pitcher's fielding record of 273 consecutive errorless chances
- May 22 Yankees turn triple-play & defeat Tigers 5-3
Bill Dickey for the Yankees
May 24 Bill Dickey replaces Joe McCarthy as New York Yankees manager
- May 28 1st night game at Yankee stadium (Senators 2, Yanks 1)
- May 30 Bama Rowell hits a home run in a baseball match - the ball shatters Bulova Clock in Ebbets Field in Brooklyn, New York
- May 30 Indianapolis 500: Race resumes after WWII hiatus, George Robson wins by 44 seconds ahead of rookie Jimmy Jackson
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