- Apr 1 Kraft Nabisco Championship Women's Golf, Mission Hills CC: Sun-Young Yoo wins sudden-death playoff on 1st extra hole after I.K. Kim misses a one-foot putt on the 72nd hole for the win
- Apr 2 74th NCAA Men's Basketball Championship: Kentucky defeats Kansas, 67-59; Wildcats guard Doron Lamb, 22 points
- Apr 3 31st NCAA Women's Basketball Championship: Baylor beats Notre Dame, 80-61; Lady Bears' second National title
- Apr 5 A three-run homer by J.P. Arencibia off Jairo Asencio gives the Toronto Blue Jays a 7-4 win over the Cleveland Indians; 16 inning game duration a MLB Opening Day record
US Masters Golf
Apr 8 76th US Masters Tournament, Augusta National GC: Bubba Watson wins on the second hole of a sudden-death playoff with South African Louis Oosthuizen
- Apr 14 165th Grand National: Daryl Jacob wins aboard Neptune Collonges; beats Sunnyhillboy in a photo finish and the closest ever GN finish
- Apr 16 116th Boston Marathon: Kenyan double; Wesley Korir wins men's section in 2:12:40; Sharon Cherop first woman in 2:31:50
- Apr 21 Chicago White Sox pitcher, Philip Humber, pitches the 21st MLB perfect game against the Seattle Mariners
- Apr 22 30-year-old woman collapses and dies during London Marathon
- Apr 23 38,000 London Marathon entrants have their home and email contacts published in a data protection breach
- Apr 26 NFL Draft: Stanford quarterback Andrew Luck first pick by Indianapolis Colts
- Apr 30 Manchester City defeat Manchester United 1-0 in what is claimed to be the biggest match in the English Premier League's history