- May 1 136th Kentucky Derby: Calvin Borel wins aboard Super Saver, his third Derby success in 4 years
- May 8 Last piece of Yankee Stadium falls in the Bronx, New York, marking the end of the two year demolition process
- May 9 Oakland A's Dallas Braden becomes 19th pitcher to throw a perfect game (4-0 vs Tampa Bay)
- May 9 PGA Players Championship, TPC at Sawgrass: South African Tim Clark fires a final round 67 for his first PGA Tour victory, 1 stroke ahead of Robert Allenby of Australia
- May 15 135th Preakness: Martin Garcia aboard Lookin At Lucky wins in 1:55.47
FA Cup Final
May 15 English FA Cup Final, Wembley Stadium, London (88,335): Chelsea beats Portsmouth,1-0; Didier Drogba scores 59' winner; Blues' 6th title
- May 15 Jessica Watson at age 16 becomes the youngest person to sail solo, non-stop and unassisted around the world
- May 16 ICC Men's Cricket T20 World Cup, Bridgetown, Barbados: England beats Australia by 7 wickets with 3 overs to spare for their first title; Player of the Series: England batsman Kevin Pietersen (248 runs)
- May 16 ICC Women's Cricket T20 World Cup, Bridgetown, Barbados: Elise Perry with 3 for 18 off 4 overs leads Australia (106/8) to 3 run victory over New Zealand 103/6
UEFA Champions League Final
May 22 UEFA Champions League Final, Madrid: Internazionale beats Bayern Munich, 2-0; Inter's 3rd title and first treble (Italian Serie A & Cup)
- May 23 NHL Western Conference Finals: Chicago Black Hawks beat San Jose Sharks, 4 games to 0
- May 24 NHL Eastern Conference Final: Philadelphia Flyers beat Montreal Canadians, 4 games to 1
- May 29 In an all South African Super 14 Rugby final, the Bulls (Pretoria) retain title, 25-17 over the Stormers (Cape Town) at the Orlando Stadium, Soweto; Morné Steyn kicks 6 penalties and a conversion for the Bulls
- May 29 Philadelphia Phillies' Roy Halladay becomes 20th pitcher to throw a perfect game (1-0 vs Florida Marlins), in Miami
- May 29 Super Rugby Final, Orlando Stadium, Soweto: Bulls (Pretoria) successfully defend their title with a 25-17 win over the Stormers (Cape Town) in an all-South African final
Indy 500
May 30 Indianapolis 500: Scotsman Dario Franchitti driving for Target Chip Ganassi Racing wins his 2nd Indy title ahead of Dan Wheldon and Marco Andretti
Senior PGA Championship
May 30 Senior PGA Championship, Colorado GC: Tom Lehman wins first of 3 Champions Tour major titles with a par on the first hole of a playoff with Fred Couples and David Frost
Baseball Players
Basketball Stars
Boxers
Footballers
NFL Stars
Tennis Champions