- Apr 4 162nd Grand National: French-bred 100/1 outsider Mon Mome, ridden by Liam Treadwell, wins by 12 lengths from defending champion Comply or Die
Kraft Nabisco Championship
Apr 5 Kraft Nabisco Championship Women's Golf, Mission Hills CC: Brittany Lincicome eagles the final hole to win her first major title, 1 stroke ahead of fellow American Cristie Kerr
- Apr 6 71st NCAA Men's Basketball Championship: North Carolina beats Michigan State, 89-72; Tar Heels' 5th national title; Ty Lawson 21 points
- Apr 7 28th NCAA Women's Basketball Championship: Connecticut beats Louisville, 76-54; Huskies' 6th national title with center Tina Charles MOP
- Apr 12 73rd US Masters Tournament, Augusta National GC: Ángel Cabrera wins his 2nd major title in a playoff with Chad Campbell and Kenny Perry; Cabrera, first Masters champion from Argentina and South America
Laureus Awards
Apr 16 Laureus World Sports Awards, (ceremony cancelled GFC): Sportsman: Usain Bolt; Sportswoman: Yelena Isinbayeva; Team: China Olympic team
- Apr 20 113th Boston Marathon: Deriba Merga of Ethiopia wins men's event in 2:08:42; Salina Kosgei of Kenya women's champion in 2:32:16
NFL Draft
Apr 25 NFL Draft: Georgia quarterback Matthew Stafford first pick by Detroit Lions