- Apr 9 At the height of his fame Babe Ruth rushed to hospital with a mysterious condition labelled “the bellyache heard round the world". Ruth reported dead by some newspapers. [1]
- Apr 14 First regular-season Chicago Cubs game broadcast on radio (WGN) by caller Quin Ryan; Cubs beat Pittsburgh Pirates, 8-2
- Apr 15 NHL's NY Americans (formerly Hamilton Tigers) 1st game, lose 3-1
- Apr 17 NY Yankee Babe Ruth has ulcer surgery
- Apr 20 29th Boston Marathon won by Charles Mellor in 2:33:00.6
- Apr 21 No baseball games played in NL due to Charles Ebbets' funeral