- Apr 15 5th Boston Marathon won for second straight year by Canadian Jim Caffrey in race record 2:29:23.6
- Apr 24 First game in baseball's American League: Chicago White Stockings win against the Cleveland Blues 8-2, other games rained out
- Apr 25 Erve Beck hits American League's 1st home run
- Apr 25 In last of 9th, Detroit Tigers, trailing by 13-4, score 10 runs to win one of greatest comebacks in baseball (1st game in Detroit)
- Apr 26 Jimmy Collins, having left the Boston Beaneaters (NL), captains and manages his first game for the Boston Americans (loses 10-6 at Baltimore Orioles)
- Apr 28 Cleveland's Bock Baker gives up a record 23 singles as White Sox beat Blues (Cleveland Blues!) 13-1
- Apr 29 27th Kentucky Derby: Jimmy Winkfield on His Eminence wins in 2:07.75
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